Healthcare Investment Advisory

From
Screening
To Exit.

Five senior healthcare executives. One integrated team. Hands-on advisory across every stage of the investment lifecycle.

5
Senior Operators
120+
Combined Years
3
Core Service Areas
Scroll
The Opportunity

Why Healthcare Is Hard to Navigate Alone

OT3 offers something distinct: the depth of a multidisciplinary team, the accountability of an embedded partner, and the continuity to stay engaged from diligence through execution — across science, regulatory, reimbursement, inorganic growth, exit planning, and IP.

Valuations can feel disconnected from industrial comparables — 25–30× multiples versus the 7–8× you know from other sectors.

CEO pitches are compelling, but independent verification of the underlying science, regulatory and reimbursement pathway, and exit thesis remains difficult.

Building a repeatable diligence framework is challenging — each deal often relies on one-off advisor relationships.

Post-close, maintaining portfolio company accountability to the milestones that justified the initial valuation remains a persistent challenge.

Who We Are

Five Domains.
One Team.

Five senior healthcare executives — not generalist consultants. Each owns a distinct domain, and together we deliver hands-on expertise across every stage of the company lifecycle, from pre-investment through to exit.

🔬

Clinical & Scientific

Technology assessment, study design, evidence strategy, pre-clinical and clinical validation to ensure next milestones are achieved.

📋

Regulatory & Quality

FDA/CE pathways, QMS, risk maps, and timeline modeling across complex regulatory environments.

💹

Commercial & Market Access

Reimbursement strategy, pricing, payer dossiers, and go-to-market plans with global and regional expertise.

🏛

Capital & Governance

Deal structuring, milestones, tranching, covenants, and board oversight designed for accountability.

⚙️

Operations & Execution

Fractional leadership, KPI frameworks, turnaround, vendor management, and manufacturing scale-up from prototyping to commercial scale.

The Team

Operator-Level Expertise

ST

Dr. Soren Thestrup-Nielsen

M.D., MBA
Capital & Governance

Independent Healthcare Investment Advisor with deep experience structuring complex life science investments and board-level governance.

AL

Dr. Achim von Leoprechting

Ph.D.
Clinical & Scientific

Strategic Advisor & Board Member with a strong track record across pre-clinical strategy, evidence generation, and scientific credibility assessment.

RocheAAAS
MP

Dr. Michele Pedrocchi

CEO, Strategic Advisor
Regulatory & Quality

CEO and Company Builder with extensive experience navigating FDA/CE regulatory pathways and scaling life science organizations globally.

Roche
PC

Paul Chapman

CEO & Advisor
Commercial & Market Access

CEO and strategic advisor with deep expertise in commercial strategy, reimbursement, and market access across global healthcare markets.

QuanterixSingulex
GB

Guido Baechler

Former CEO, Tecan Group AG
Operations & Execution

Former CEO of Tecan Group AG with a career spanning operational transformation, manufacturing scale-up, and global commercial execution in life sciences.

Tecan Group
What We Deliver

Six Core Capabilities

01

Rapid Screening

Scientific credibility assessment across the investment thesis. Output is a clear invest / pass / conditions recommendation before committing to full diligence.

02

Deep Diligence

We map the risk register, stress-test management's assumptions, and benchmark against comparable programs across science, regulatory, commercial, and operations.

03

Deal Structuring Support

Diligence findings translated into term-sheet guidance: milestone-linked tranches, covenants, governance rights, and board representation recommendations.

04

Portfolio Oversight

Quarterly KPI reviews, board-level reporting, and milestone tracking across the portfolio. Companies are held to the operational targets that underpinned the investment thesis.

05

Active Execution Support

Fractional executive leadership for portfolio companies requiring operational intervention — leadership assessment, team restructuring, pivot strategy, and go-to-market realignment.

06

Network & Introductions

Portfolio companies are connected to vetted CROs, CDMOs, regulatory advisors, and co-investors through the OT3 network. Direct introductions, no markups.

The Investment Journey

Your Journey With OT3

OT3 remains engaged across every stage — from initial screening through validation, scaling, and exit.

1

Sourcing

  • Curated, vetted opportunity pipeline
  • Portfolio assessment vs. your strategy
  • Science + team credibility pre-screening
  • Health equity and impact lens
2

Diligence

  • Full multidisciplinary assessment
  • CEO and team evaluation
  • Regulatory + reimbursement risk map
  • IP and competitive moat analysis
  • Project plan and milestone validation
3

Deal Structuring

  • Milestone-linked tranche design
  • Capital runway planning
  • Governance rights + board setup
  • OT3 board seat representation
  • Non-dilutive grant application support
4

Scale & Exit

  • Milestone tracking + accountability
  • Fractional executive leadership
  • Exit catalyst identification
  • M&A readiness, valuation bridging
  • Strategic partner introductions
How We Engage

Three Engagement Models

Three engagement models, each with direct executive involvement.

Advisory + Diligence

Diligence & Investment Recommendation

Multidisciplinary diligence across science, regulatory, commercial, and operations, delivered in a single integrated process. Output includes an investment recommendation and term-sheet guidance.

Project-based · $150K – $400K

Advisory + Intervention

Operational Support for Portfolio Companies

Fractional executive support for portfolio companies requiring operational intervention. Scope is defined per engagement and can include leadership, commercial restructuring, and go-to-market realignment.

Retainer + success · TBD per engagement

Portfolio Partnership

Ongoing Portfolio Oversight

Structured oversight across the portfolio: quarterly KPI reviews, board-level reporting, milestone accountability, exit planning, and introductions to strategic partners and co-investors.

Annual retainer · scoped per portfolio
Illustrative Scenarios

OT3 In Action

SCENARIO 01

Pre-Investment Diligence

Situation

Investor evaluating a diagnostics start-up claiming FDA 510(k) clearance in 18 months and $50M Series B at $200M pre-money.

OT3 Action

OT3 mapped the full regulatory path, identified a 12-month gap in the clinical evidence plan, and modelled three reimbursement scenarios with payer probability scores.

Investor re-structured terms: milestone-linked tranches tied to 510(k) submission + first payer coverage, reducing downside by ~40%.
SCENARIO 02

Distressed Portfolio Rescue

Situation

Portfolio company (cardiology SaaS) stalling at $8M ARR — CEO resistant to board guidance, two key commercial hires failed.

OT3 Action

OT3 stepped in as fractional Executive Chair, completed a leadership assessment, replaced the commercial lead, connected the team with key strategic partners, and rebuilt the go-to-market playbook in 90 days.

ARR trajectory restored; company re-financed at target valuation 8 months later.
SCENARIO 03

First-Time Healthcare Entry

Situation

Investor with industrial background wanting to enter life sciences but lacking a credible evaluation framework.

OT3 Action

OT3 built a repeatable diligence scorecard across 5 dimensions, screened 12 opportunities, and ran a structured 6-week deep-dive on 2 finalists.

Investor made their first healthcare investment with full conviction; OT3 retained for ongoing portfolio oversight and exit planning.

Scenarios are illustrative and based on composite deal experience.

Get Started

Ready to Invest
With Conviction?

Start with a 30-minute conversation. No commitment required — just a direct discussion about your investment thesis and where OT3 can add the most value.

1

30-minute intro call to understand your investment thesis and current healthcare focus

2

Tailored proposal for a first engagement: diligence, oversight, or strategy

3

Pilot project on one opportunity — no investment required upfront

Start the Conversation